Health Sciences
Peter Huckfeldt, PhD (he/him/his)
Associate Professor
Division of Health Policy & Management
University of Minnesota School of Public Health
Minneapolis, Minnesota, United States
Charles Semelka, MD, MS
Assistant Professor
Internal Medicine - Gerontology & Geriatric Medicine
Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States
John Jakicic, PhD, FACSM, FTOS
Professor
Department of Internal Medicine
University of Kansas Medical Center
Kansas City, Kansas, United States
Charles Semelka, MD, MS
Assistant Professor
Internal Medicine - Gerontology & Geriatric Medicine
Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States
Mark Espeland, PhD (he/him/his)
Professor
Internal Medicine - Gerontology and Geriatric Medicine
Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States
Denise Houston, PhD, RD, FGSA (she/her/hers)
Professor
Internal Medicine - Gerontology & Geriatric Medicine
Wake Forest University School of Medicine
Winston Salem, North Carolina, United States
Ian Davis, MA
Graduate Research Assistant
Department of Pharmaceutical and Health Economics
University of Southern California
Los Angeles, California, United States
Mid-life weight loss and maintenance is often recommended as a means to improve health later in life, however its long-term benefits have not been rigorously established. The Action for Health in Diabetes (Look AHEAD) randomized controlled trial compared an intensive lifestyle intervention (ILI) designed to induce and maintain a 7% weight loss through caloric restriction and increased physical activity with a control condition of diabetes support and education (DSE) in 5,145 individuals aged 45-76 years with type 2 diabetes and overweight/obesity over up to 11 years of follow-up beginning in 2001. Although the ILI group had greater initial improvements in cardiovascular disease risk factors compared to DSE, there were no overall differences in the incidence of the trial’s primary and secondary cardiovascular outcomes between the ILI and DSE groups. However, ILI did have a positive impact on diabetes control and complications, depression, physical health–related quality of life, and health care use and costs. Subsequently, the Look AHEAD trial transitioned to an in-person observational study in 2012 to assess the long-term benefits and potential harms of an ILI, which continued for 10 years before transitioning to phone-only observational period in 2022 – the Look AHEAD Aging study. This symposium will describe the long-term impact of the lifestyle intervention and the effect of diabetes-related risk factors on self-reported vision and hearing (Espeland and colleagues), nutritional risk (Houston and colleagues), self-reported disability in basic activities of daily living, instrumental activities of daily living, and mobility (Semelka and colleagues), and multi-morbidity (Davis and colleagues).
Individual Symposium Abstract First Author: Charles T. Semelka, MD, MS – Wake Forest University School of Medicine
Individual Symposium Abstract First Author: Mark A. Espeland, PhD (he/him/his) – Wake Forest University School of Medicine
Individual Symposium Abstract First Author: Denise K. Houston, PhD, RD, FGSA (she/her/hers) – Wake Forest University School of Medicine
Individual Symposium Abstract First Author: Ian Davis, MA – University of Southern California