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Premranjan Kumar, PhD (he/him/his)

Instructor
Baylor College of Medicine
Houston, Texas, United States

I am investigating the role of glutathione in mitochondrial metabolism in aging, Alzheimer’s disease (AD), and aging HIV patients. We have found in the Randomized, double-blinded placebo-controlled clinical trial that correcting glutathione deficiency by supplementing glutathione precursor amino-acids glycine and N-acetylcysteine (GlyNAC) in older humans reverses mitochondrial impairment and improves physical function, insulin resistance, endothelial function, and inflammation. In another open-label clinical study on HIV and older, we found that cognition improved with GlyNAC supplementation. Our translation study on aged C57BL6 mice also showed that GlyNAC supplementation improves glucose metabolism in the brain and corrects impaired cognition. Based on these findings, we are conducting a randomized double-blinded clinical trial of GlyNAC supplementation on mild cognitive impaired and Alzheimer’s disease patients. I am also exploring the role of thyroid hormone on neuronal cells.

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