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Symposium

Interdisciplinary

Restoring Glutathione Has Benefits for Older Adults and Mice

Wednesday, November 13, 2024
12:00 PM – 1:30 PM PST
Location: Room 608

The role and importance of mitochondrial function and glutathione is not well recognized by clinicians
Glutathione is the most abundant intracellular anti-oxidant and is responsible for detoxifying many reactive, potentially harmful molecules and is most older adults are glutathione deficient because of low free Cysteine and especially Glycine.
Supplementation with Glycine and N-Acetyl Cysteine is able to restore cellular glutathione.
This symposium will fill these gaps by providing knowledge about glutathione, its role in defending anti-oxidant status, the deficient precursors, and the results when glutathione is restored by providing the precursors and the potential sex differences in these effects.

Learning Objectives:

  • Many of the Geroscience approaches are expensive, and unaffordable to the most older adults. GlyNAC, two widely available nutritional supplements, have few of these barriers.
  • While we think of the aging process as uniform, increasing evidence suggests that the process may be different in males and females requiring different foci to address them.

Presentations:

  • 12:00 PM – 1:30 PM PST
    GlyNAC and the Aging Mouse Heart: Sex-Related Differences and Outcomes

    Individual Symposium Abstract First Author: Katarzyna A. Cieslik, PhD (she/her/hers) – Houston Methodist Hospital

  • 12:00 PM – 1:30 PM PST
    GlyNAC Supplementation Lowers Postprandial Inflammation and Oxidative Stress to Promote Health in Older Humans

    Individual Symposium Abstract First Author: Rajagopal V. Sekhar, MD – Baylor College of Medicine

  • 12:00 PM – 1:30 PM PST
    Brain Glutathione, Mitochondria, Glucose Metabolism, and Cognition in Aged Mice: Impact of GlyNAC Supplementation

    Individual Symposium Abstract First Author: Rajagopal V. Sekhar, MD – Baylor College of Medicine