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Joao Passos, PhD (he/him/his)

Professor
Mayo Clinic
Rochester, Minnesota, United States

Dr. Joao Passos is a Professor at Mayo Clinic withmore tha 20 years’ experience in the field of biology of aging. He directs the Cell and Molecular Aging laboratory at Mayo Clinic and holds the positions of Associate Director of the Robert and Arlene Kogod Center on Aging and director of its Discovery Science Theme. Dr. Passos has led an independent research program focused on cellular senescence and mechanisms of aging since 2010, firstly at the Newcastle University Institute for Ageing in the UK and since 2018 at Mayo Clinic. His laboratory has been continuously funded by several UK, European and US funding bodies since its inception. He has published more than 120 papers about biology of aging.
Dr. Passos’ laboratory has made several important contributions to the understanding of the mechanisms driving cellular senescence during aging, with a particular emphasis on telomeres and mitochondria. His investigations have provided critical insights into how chronic DNA damage signaling from irreparable telomeric damage triggers cellular senescence in response to stress. Furthermore, his laboratory has shown that mitochondria are key regulators of the proinflammatory phenotype characteristic of senescent cells.

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