JGMS Editor’s Choice Articles of 2023: Risk and Recovery of Functional Decline and Frailty

Chair(s)

• 

  Lewis Lipsitz, MD

  Director, Marcus Institute for Aging Research
  Hinda and Arthur Marcus Institute for Aging Research
  Hebrew SeniorLife
  Boston, Massachusetts, United States

Discussant(s)

• 

  Dae Kim, MD, ScD

  Associate Professor
  Medicine
  Harvard Medical School
  Boston, Massachusetts, United States

Individual Symposium Abstract First Author(s)

• 

  Courtney Millar, PhD (she/her/hers)

  Assistant Scientist II
  Hinda and Arthur Marcus Institute for Aging Research
  Hebrew SeniorLife
  Roslindale, Massachusetts, United States
• 

  Nicholas Rowan, MD

  Associate Professor of Otolaryngology-Head & Neck Surgery and Neurosurgery
  Otolaryngology-Head and Neck Surgery
  Johns Hopkins University School of Medicine
  Baltimore, Maryland, United States
• 

  Rajagopal Sekhar, MD

  Professor, Section of Endocrinology, Diabetes and Metabolism
  Medicine/Endocrinology
  Baylor College of Medicine
  Houston, Texas, United States
• 

  Theresa Mau, PhD (she/her/hers)

  Scientist I
  Research Institute
  California Pacific Medical Center
  San Francisco, California, United States

This symposium will present four 2023 “Editor’s Choice” articles from the Journal of Gerontology Medical Sciences that focus on the risk and recovery of functional decline and frailty. Courtney Millar and her colleagues, in their article “Association of Proinflammatory Diet With Frailty Onset Among Adults With and Without Depressive Symptoms: Results From the Framingham Offspring Study” examine the association between an inflammatory diet and increased odds of frailty in those with depressive symptoms. Nicholas Rowan and his coauthors, in “The Association of Peripheral and Central Olfaction With Frailty in Older Adults” examine olfactory impairment, specifically olfactory identification and sensitivity, as a potential biomarker and risk factor for frailty. “Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial”, written by Sekhar Rajagopal and colleagues, studies the effects of GlyNAC (combination of glycine and N-acetylcysteine [NAC]) supplementation on hallmarks of aging in older adults. Theresa Mau and coauthors, in their article, “Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging,” examine the associations between mitochondrial energetics and functional outcomes, including leg power and cardiorespiratory fitness. Our discussant, Roger Fielding, will highlight commonalities and lessons learned from these studies.

Presentations:

• 8:00 AM – 9:30 AM PST

  Association of Pro-Inflammatory Diet With Frailty Onset Among Adults With and Without Depressive Symptoms
  

  Individual Symposium Abstract First Author: Courtney Millar, PhD (she/her/hers) – Hebrew SeniorLife
• 8:00 AM – 9:30 AM PST

  The Association of Peripheral and Central Olfaction With Frailty in Older Adults
  

  Individual Symposium Abstract First Author: Nicholas R. Rowan, MD – Johns Hopkins University School of Medicine
• 8:00 AM – 9:30 AM PST

  GlyNAC Supplementation in Older Adults Improves Glutathione, Mitochondria, Aging Hallmarks, and Function
  

  Individual Symposium Abstract First Author: Rajagopal V. Sekhar, MD – Baylor College of Medicine
• 8:00 AM – 9:30 AM PST

  Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in SOMMA.
  

  Individual Symposium Abstract First Author: Theresa Mau, PhD (she/her/hers) – California Pacific Medical Center